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作为一种具有临床显著意义的特征,吸入物戒断出现在了吸入物依赖障碍中。

Inhalant withdrawal as a clinically significant feature of inhalant dependence disorder.

机构信息

University of Michigan, School of Social Work, 1080 S University Avenue, Ann Arbor, MI 48109, United States.

出版信息

Med Hypotheses. 2009 Dec;73(6):935-7. doi: 10.1016/j.mehy.2009.06.036. Epub 2009 Jul 24.

Abstract

Inhalant use is the intentional inhalation of vapors from commercial products or specific chemical agents for the purpose of achieving intoxication. Inhalants are among the most common and pernicious forms of substance use and the least studied of the major drugs. Diagnosis of inhalant dependence, according to the DSM-IV [Weintraub E, Gandhi D, Robinson C. Medical complications due to mothball abuse. South Med J 2000;93:427-9] excludes inhalant withdrawal symptoms, as expert opinion has suggested that an inhalant withdrawal syndrome is neither common nor clinically significant. This article draws from multiple sources of data to suggest that withdrawal symptoms can be part of inhalant dependence and are clinically significant. This hypothesis needs rigorous evaluation to ensure the diagnostic validity of inhalant use disorders.

摘要

吸入剂使用是指为了达到兴奋效果而有意吸入商业产品或特定化学物质的蒸气。吸入剂是最常见和最有害的物质使用形式之一,也是主要药物中研究最少的一种。根据 DSM-IV [Weintraub E, Gandhi D, Robinson C. Medical complications due to mothball abuse. South Med J 2000;93:427-9],吸入剂依赖的诊断不包括吸入剂戒断症状,因为专家意见认为,吸入剂戒断综合征既不常见也无临床意义。本文从多个数据源中得出结论,认为戒断症状可能是吸入剂依赖的一部分,且具有临床意义。这一假设需要经过严格的评估,以确保吸入剂使用障碍的诊断有效性。

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本文引用的文献

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Baclofen in the management of inhalant withdrawal: a case series.巴氯芬用于治疗吸入性物质戒断:病例系列
Prim Care Companion J Clin Psychiatry. 2008;10(1):48-51. doi: 10.4088/pcc.v10n0108.
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Treatment of inhalant dependence with lamotrigine.用拉莫三嗪治疗吸入剂依赖。
Prog Neuropsychopharmacol Biol Psychiatry. 2007 Apr 13;31(3):769-71. doi: 10.1016/j.pnpbp.2006.12.016. Epub 2006 Dec 29.
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Sudden death after isobutane sniffing: a report of two forensic cases.异丁烷吸入后猝死:两例法医案例报告
Int J Legal Med. 2006 May;120(3):168-73. doi: 10.1007/s00414-005-0062-x. Epub 2005 Dec 21.
7
Inhalant abuse and dependence among adolescents in the United States.美国青少年中的吸入剂滥用与依赖问题。
J Am Acad Child Adolesc Psychiatry. 2004 Oct;43(10):1206-14. doi: 10.1097/01.chi.0000134491.42807.a3.
9
Inhalant dependence and withdrawal symptoms.吸入剂依赖及戒断症状。
J Am Acad Child Adolesc Psychiatry. 2000 Jun;39(6):679-80. doi: 10.1097/00004583-200006000-00004.

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