Park K, Cherrick H M, Min B M, Park N H
Section of Oral Biology, UCLA School of Dentistry.
Oral Surg Oral Med Oral Pathol. 1990 Aug;70(2):186-91. doi: 10.1016/0030-4220(90)90117-b.
Previous investigations have demonstrated that herpes simplex virus (HSV) increased the oral carcinogenic activity of 7,12-dimethylbenz[a]anthracene (DMBA) probably by enhancing the DMBA-induced amplification and overexpression of c-erb-B-1 proto-oncogene in hamster buccal pouch epithelium. The present study investigated the effect of active type 1 HSV (HSV-1) immunization on the development of oral cancer induced by HSV-1 and DMBA, alone or in combination, in the hamster buccal pouch. The results were similar to our previous report in that HSV-1 significantly enhanced the oncogenic effect of DMBA, and the numbers of pouches harboring tumor nodules and the numbers and sizes of tumors developed by topical DMBA were significantly increased by HSV-1 inoculation to the site of the DMBA application. Although HSV-1 immunization did not alter the carcinogenic activity of DMBA in animals receiving topical DMBA in combination with mock inoculation, it prevented the cocarcinogenic effect of HSV-1 in animals receiving topical DMBA in conjunction with HSV-1 inoculation. These data indicate that active HSV-1 immunization completely obstructs the co-oncogenic effect of HSV-1 in the oral cavity of hamsters.
先前的研究表明，单纯疱疹病毒（HSV）可能通过增强7,12-二甲基苯并[a]蒽（DMBA）诱导的仓鼠颊囊上皮细胞中c-erb-B-1原癌基因的扩增和过表达，来提高DMBA的口腔致癌活性。本研究调查了1型活性HSV（HSV-1）免疫对HSV-1和DMBA单独或联合诱导的仓鼠颊囊口腔癌发生发展的影响。结果与我们之前的报告相似，即HSV-1显著增强了DMBA的致癌作用，在DMBA应用部位接种HSV-1可显著增加出现肿瘤结节的颊囊数量以及局部应用DMBA所产生肿瘤的数量和大小。尽管HSV-1免疫并未改变联合假接种局部应用DMBA的动物中DMBA的致癌活性，但它可防止联合HSV-1接种局部应用DMBA的动物中HSV-1的促癌作用。这些数据表明，活性HSV-1免疫完全阻断了HSV-1在仓鼠口腔中的协同致癌作用。
