Academic Medical Center, University of Amsterdam, Department of Psychiatry, Amsterdam Institute for Addiction Research, Amsterdam, The Netherlands.
Neurosci Biobehav Rev. 2010 Jan;34(1):87-107. doi: 10.1016/j.neubiorev.2009.07.007. Epub 2009 Jul 24.
The purpose of this review is to gain more insight in the neuropathology of pathological gambling (PG) and problem gambling, and to discuss challenges in this research area. Results from the reviewed PG studies show that PG is more than just an impulse control disorder. PG seems to fit very well with recent theoretical models of addiction, which stress the involvement of the ventral tegmental-orbito frontal cortex. Differentiating types of PG on game preferences (slot machines vs. casino games) seems to be useful because different PG groups show divergent results, suggesting different neurobiological pathways to PG. A framework for future studies is suggested, indicating the need for hypothesis driven pharmacological and functional imaging studies in PG and integration of knowledge from different research areas to further elucidate the neurobiological underpinnings of this disorder.
本文旨在深入了解病理性赌博（PG）和赌博问题的神经病理学，并讨论该研究领域的挑战。已发表的 PG 研究结果表明，PG 不仅仅是一种冲动控制障碍。PG 似乎非常符合成瘾的最新理论模型，这些模型强调了腹侧被盖区-眶额皮层的参与。根据游戏偏好（老虎机与赌场游戏）区分 PG 类型似乎很有用，因为不同的 PG 群体显示出不同的结果，这表明存在不同的神经生物学途径通向 PG。本文提出了一个未来研究的框架，指出需要对 PG 进行假设驱动的药理学和功能成像研究，并整合来自不同研究领域的知识，以进一步阐明这种疾病的神经生物学基础。
