Zipfel Burkhart, Buz Semih, Hammerschmidt Robert, Hetzer Roland
Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Berlin, Germany.
Ann Thorac Surg. 2009 Aug;88(2):498-504. doi: 10.1016/j.athoracsur.2009.04.042.
Safe fixation of endovascular stent grafts in thoracic aortic disease often requires covering of the left subclavian artery (LSA) with the stent graft. It is controversial whether this occlusion can be done without additional risk of ischemic complications.
In 102 patients treated with endovascular stent grafts, the LSA was covered. In a nonrandomized clinical practice, unprotected occlusion of the LSA was performed in 63 patients (61%), whereas 39 patients underwent extrathoracic subclavian to carotid artery revascularization before (n = 28) or concomitantly with (n = 11) the endovascular procedure.
Left cerebral ischemia occurred in 11% of the unprotected group and in 5% of the protected group. The difference was not statistically significant. The difference in spinal cord ischemia was insignificant owing to the low incidence in general, but the covered length of the aorta was significantly longer in the protected group. Arm ischemia after unprotected LSA occlusion occurred in 25%.
The interpretation of the results remains speculative because many factors contribute to left cerebral ischemia. However, in terms of overall complications, there is a significant difference in favor of the group protected by revascularization of the LSA either before or simultaneously with stent grafting. Arm ischemia is mostly mild and can be managed secondarily. Subclavian revascularization is associated with relatively low risk and should be considered in advance, at least when extended covering of the thoracic aorta is intended.
在胸主动脉疾病中,血管内支架移植物的安全固定通常需要用支架移植物覆盖左锁骨下动脉(LSA)。这种闭塞是否会在没有缺血性并发症额外风险的情况下进行存在争议。
在102例接受血管内支架移植物治疗的患者中,LSA被覆盖。在非随机临床实践中,63例患者(61%)进行了LSA的无保护闭塞,而39例患者在血管内手术前(n = 28)或同时(n = 11)进行了胸外锁骨下动脉至颈动脉血运重建。
无保护组11%的患者发生左脑缺血,保护组为5%。差异无统计学意义。脊髓缺血的差异不显著,因为总体发生率较低,但保护组主动脉的覆盖长度明显更长。无保护LSA闭塞后25%的患者发生手臂缺血。
由于许多因素导致左脑缺血,结果的解释仍具有推测性。然而,就总体并发症而言,在LSA血管重建术前或与支架植入同时进行保护的组有显著差异。手臂缺血大多为轻度,可进行二期处理。锁骨下动脉血运重建的风险相对较低,至少在打算广泛覆盖胸主动脉时应提前考虑。