用于痕量分析水平下基于¹⁹F核磁共振的亚砜立体化学分析的手性氟标记参考标准品的合成。

Synthesis of chiral fluorine-tagged reference standards for the (19)F NMR-based stereochemical analysis of sulfoxides at trace analytical levels.

作者信息

Tremblay Amy E, Lao Kim Y Y, Hodgson Derek J, Dawson Brian, Buist Peter H

机构信息

Ottawa-Carleton Chemistry Institute, Department of Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada.

出版信息

Bioorg Med Chem Lett. 2009 Sep 1;19(17):5146-50. doi: 10.1016/j.bmcl.2009.07.026. Epub 2009 Jul 10.

DOI:10.1016/j.bmcl.2009.07.026

PMID:19632835

Abstract

Chiral fluorine-tagged sulfoxides of known absolute configuration have been synthesized. These compounds are required as reference standards to validate a (19)F NMR-based micromethod for the stereochemical analysis of biosynthetic fatty acyl sulfoxides.

摘要

已合成出具有已知绝对构型的手性氟标记亚砜。这些化合物是验证基于¹⁹F核磁共振的微量方法用于生物合成脂肪酰亚砜立体化学分析所需的参考标准品。