Fitzgerald Paul B, Maller Jerome J, Hoy Kate, Farzan Faranak, Daskalakis Zafiris J
Monash Alfred Psychiatry Research Centre, The Alfred and Monash University School of Psychology, Psychiatry and Psychological Medicine, Melbourne, Vic. 3004, Australia.
Clin Neurophysiol. 2009 Sep;120(9):1706-10. doi: 10.1016/j.clinph.2009.06.019. Epub 2009 Jul 25.
The induction of long interval cortical inhibition (LICI) in motor cortex with paired pulse transcranial magnetic stimulation (ppTMS) is an established paradigm for the assessment of cortical inhibition, proposed to be related to GABA(B) receptor inhibitory neurotransmission. This study aimed to further evaluate recent methods of the assessment of LICI in non motor regions with ppTMS and electroencephalography (EEG).
ppTMS was applied using a single coil to the motor and dorsolateral prefrontal cortex (DLPFC) in 14 healthy subjects, and in the parietal lobe in 5 of those subjects.
In the motor cortex, LICI resulted in significant suppression in mean cortical evoked activity on EEG between 75 and 250 ms following delivery of the test stimulus. Maximal inhibition was seen from 50 to 250 ms in DLPFC, and between 50 and 175 ms in the parietal lobe.
ppTMS may be used to produce LICI in several cortical regions with a time course similar to known GABA(B) activity.
ppTMS induction of LICI can be recorded by combining TMS with EEG and seems to relate to GABA(B) activity.
采用配对脉冲经颅磁刺激（ppTMS）在运动皮层诱导长时程皮层抑制（LICI）是评估皮层抑制的既定范式，该范式被认为与GABA(B)受体抑制性神经传递有关。本研究旨在进一步评估使用ppTMS和脑电图（EEG）在非运动区域评估LICI的最新方法。
对14名健康受试者的运动皮层和背外侧前额叶皮层（DLPFC）以及其中5名受试者的顶叶使用单线圈施加ppTMS。
在运动皮层，LICI导致在施加测试刺激后75至250毫秒之间脑电图上平均皮层诱发活动显著抑制。在DLPFC中，50至250毫秒时出现最大抑制，在顶叶中则在50至175毫秒之间出现最大抑制。
ppTMS可用于在几个皮层区域产生LICI，其时程与已知的GABA(B)活性相似。
通过将TMS与EEG相结合可记录ppTMS诱导的LICI，且其似乎与GABA(B)活性有关。
