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印度b型流感嗜血杆菌疫苗的群体效应

Community effect of Haemophilus influenzae type b vaccination in India.

作者信息

Verghese Valsan Philip, Friberg Ingrid K, Cherian Thomas, Raghupathy Palany, Balaji V, Lalitha M K, Thomas Kurien, John T Jacob, Steinhoff Mark C

机构信息

Department of Child Health, Christian Medical College, Vellore, India.

出版信息

Pediatr Infect Dis J. 2009 Aug;28(8):738-40. doi: 10.1097/INF.0b013e318199f2a1.

DOI:10.1097/INF.0b013e318199f2a1
PMID:19633518
Abstract

We assessed the effect of distribution of Haemophilus influenzae type b (Hib) vaccine in the private health care sector on Hib meningitis admissions at a referral hospital in India. The annual mean number of Hib cases was 10.7 before Hib vaccine introduction, falling to 3.8 cases following introduction (P < 0.0001). By contrast, the mean of annual numbers of pneumococcal cases were 3.0 and 4.6, (P = 0.55). Even at relatively low coverage through private sector distribution, Hib vaccine has significant community impact on Hib disease.

摘要

我们评估了印度一家转诊医院私立医疗保健部门中b型流感嗜血杆菌(Hib)疫苗的分发对Hib脑膜炎住院病例的影响。在引入Hib疫苗之前,Hib病例的年均数量为10.7例,引入后降至3.8例(P < 0.0001)。相比之下,肺炎球菌病例的年均数量分别为3.0例和4.6例(P = 0.55)。即使通过私营部门分发的覆盖率相对较低,Hib疫苗对Hib疾病仍具有显著的社区影响。

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