Department of Plastic Surgery and Burn Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Melanoma Res. 2009 Oct;19(5):275-82. doi: 10.1097/CMR.0b013e32832eabd5.
Regression of metastatic melanoma is a rare event, and review of the literature reveals a total of 76 reported cases since 1866. The proposed mechanisms include immunologic, endocrine, inflammatory and metastatic tumour nutritional factors. We conclude from this review that although the precise mechanisms remain unknown, some event must trigger the immune system to produce a stronger than normal response that results in regression of the melanoma metastases. Immunologic studies of patients with regression may disclose the underlying mechanisms and lead to new therapies of disseminated melanoma.
转移性黑色素瘤的消退是一种罕见的现象，文献回顾显示，自 1866 年以来，总共报告了 76 例。提出的机制包括免疫、内分泌、炎症和转移性肿瘤营养因素。我们从这篇综述中得出结论，尽管确切的机制仍不清楚，但一定有某种事件触发了免疫系统产生比正常情况下更强的反应，从而导致黑色素瘤转移的消退。对消退患者的免疫研究可能揭示潜在的机制，并为播散性黑色素瘤的新疗法提供依据。
