Pellin MacKenzie A
School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI 53706, USA.
Vet Sci. 2022 Oct 28;9(11):597. doi: 10.3390/vetsci9110597.
The Oncept melanoma vaccine is xenogeneic DNA vaccine targeting tyrosinase. It is USDA approved for treatment of stage II to III canine oral melanoma and is also used off-label for melanomas arising in other locations and in other species. While the vaccine appears safe, the published data is mixed as to whether it provides a survival benefit, and the use of the vaccine is somewhat controversial in the veterinary oncology community. In this paper, the published literature describing the use of Oncept is reviewed and evaluated.
Oncept黑色素瘤疫苗是一种针对酪氨酸酶的异种DNA疫苗。它已获得美国农业部批准，用于治疗II至III期犬口腔黑色素瘤，也可用于其他部位和其他物种发生的黑色素瘤的非标签治疗。虽然该疫苗看起来是安全的，但关于它是否能带来生存益处，已发表的数据存在分歧，并且在兽医肿瘤学界，该疫苗的使用存在一定争议。在本文中，对描述Oncept使用情况的已发表文献进行了综述和评估。
