Leeds General Infirmary, Great George Street, Leeds LS13EX, UK.
Department of Radiology, Leeds General Infirmary, UK.
Eur J Surg Oncol. 2014 Jan;40(1):34-41. doi: 10.1016/j.ejso.2013.09.026. Epub 2013 Oct 7.
Metastatic melanoma is poorly understood. Regression of primary lesions has been associated with poor prognosis, but spontaneous regression of all metastatic disease is clearly beneficial. A patient's own immune responses occasionally appear to stimulate spontaneous regression of metastatic disease in melanoma.
We present six interesting cases of complete or nearly complete spontaneous regression of metastatic melanoma, suggest possible causes and review the literature.
These cases show clear radiological, pathological or clinical evidence of spontaneous regression of metastatic melanoma. This remains a poorly understood phenomena warranting further investigation and may prove useful in the development of immune mediated solutions.
转移性黑色素瘤的发病机制尚不清楚。原发灶的消退与不良预后相关，但所有转移性疾病的自发消退显然是有益的。患者自身的免疫反应似乎偶尔会刺激黑色素瘤转移性疾病的自发消退。
我们报告了 6 例转移性黑色素瘤完全或几乎完全自发消退的有趣病例，提出了可能的原因并复习了文献。
这些病例显示了转移性黑色素瘤自发消退的明确的影像学、病理学或临床证据。这仍然是一种尚未被充分理解的现象，值得进一步研究，并且可能对免疫介导解决方案的开发有用。
