Klinik für Allgemeine und Thoraxchirurgie, Universitätsklinikum Schleswig-Holstein, Arnold-Heller-Strasse 7, Kiel, Germany.
Dtsch Arztebl Int. 2008 Feb;105(6):101-7. doi: 10.3238/arztebl.2008.0101. Epub 2008 Feb 8.
Liver transplantation is the first-line therapy in treatment of end-stage liver diseases. Due to the mismatch of available donor organs and growing waiting lists in Germany, live donation is of great interest.
Selective literature review.
Pediatric living donor liver transplantation almost eliminated waiting list mortality in children and achieved excellent short and long term survival. The situation in adult-to-adult living donor liver transplantation is different, due to the need for extensive donor resection and smaller graft volume for the recipient. Careful donor evaluation and defined selection criteria are essential to minimize the donor's risk and to achieve results comparable to whole organ transplantation. Living donor liver transplantation offers the recipient certain advantages such as superior graft quality, but the procedure should be reserved for selected patients. Donor safety is the highest priority in this procedure. Living donor transplantation should remain in the hands of experienced centers.
肝移植是治疗终末期肝病的首选疗法。由于德国可供使用的捐献器官与不断增长的等待名单之间不匹配，活体捐献引起了广泛关注。
选择性文献回顾。
儿科活体供肝移植几乎消除了儿童在等待名单上的死亡率，并取得了出色的短期和长期存活率。成人对成人活体供肝移植的情况则不同，这是因为需要进行广泛的供体切除，并且受体的移植物体积较小。仔细的供体评估和明确的选择标准对于将供体的风险最小化并取得与全器官移植相当的结果至关重要。活体供肝移植为受者提供了一些优势，如更好的移植物质量，但该手术应保留给特定的患者。在该手术中，供体安全是重中之重。活体供肝移植应继续由经验丰富的中心进行。
