Department of Pediatrics, Advanced Pediatric Centre, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012, India.
Rheumatol Int. 2010 Apr;30(6):771-4. doi: 10.1007/s00296-009-1065-6. Epub 2009 Jul 25.
The objective of the study was to evaluate the epidemiologic trends (1993-2008) in Kawasaki disease (KD) and Henoch Schonlein purpura (HSP) among children as seen in a tertiary care north Indian hospital. A hospital-based retrospective chart analysis of all the patients diagnosed with KD and HSP in our pediatric rheumatology clinic from January 1993 to December 2008 was performed. The diagnosis of KD and HSP was based on the American Heart Association and American College of Rheumatology criteria respectively. The collected data were analyzed for any yearly or seasonal trends in the incidence of the two diseases. KD was diagnosed in 196 patients (135 males, 61 females, ratio 2.21:1), while HSP was diagnosed in 209 patients (155 males, 54 females, ratio 2.87:1). The median age at the time of diagnosis was 5.1 +/- 3.04 years (range 4 months-14 years) for KD and 6.9 +/- 2.98 years (range 1-17 years) for HSP. Over this 16-year period, the number of patients diagnosed with KD progressively increased from 1993 to 2008 (p < 0.001, chi-square test) with a clear majority of these (162 cases, 82.6%) being diagnosed in the last 8 years. The number of children diagnosed with HSP progressively increased from 1993 to 1997, after which it has remained relatively uniform, and only 93 cases (44.5%) were diagnosed in the last 8-year period (p > 0.05, chi-square test). However, both the diseases exhibited a comparable seasonal trend in the distribution with a noticeable peak being discernible in the months of October and November. KD has shown a rising trend over the recent years in our hospital. Since 2004; the annual number of KD cases has outnumbered the HSP cases. Seasonal predilection is noticeable for both conditions. This is the first hospital-based report on epidemiological trends of KD and HSP from a developing country.
本研究旨在评估一家印度北部三级保健医院中儿童川崎病（KD）和过敏性紫癜（HSP）的流行病学趋势（1993-2008 年）。我们对 1993 年 1 月至 2008 年 12 月在我院儿科风湿病科被诊断为 KD 和 HSP 的所有患者进行了医院病历回顾性分析。KD 和 HSP 的诊断分别基于美国心脏协会和美国风湿病学会的标准。我们对两种疾病的发病率的任何年度或季节性趋势进行了分析。共诊断出 196 例 KD 患者（男 135 例，女 61 例，男女比例为 2.21:1），209 例 HSP 患者（男 155 例，女 54 例，男女比例为 2.87:1）。KD 的中位发病年龄为 5.1+/-3.04 岁（范围 4 个月-14 岁），HSP 为 6.9+/-2.98 岁（范围 1-17 岁）。在这 16 年期间，被诊断为 KD 的患者人数从 1993 年到 2008 年逐渐增加（p < 0.001，卡方检验），其中绝大多数（162 例，82.6%）是在最近 8 年被诊断的。被诊断为 HSP 的儿童人数从 1993 年到 1997 年逐渐增加，此后相对稳定，只有 93 例（44.5%）是在最近 8 年被诊断的（p > 0.05，卡方检验）。然而，这两种疾病的分布都有明显的季节性趋势，10 月和 11 月的发病高峰明显。KD 在我院近年来呈上升趋势。自 2004 年以来，KD 每年的发病人数超过 HSP。两种疾病都有明显的季节性倾向。这是来自发展中国家的第一份关于 KD 和 HSP 的流行病学趋势的医院报告。
