Samadi M, Rashid R J, Ghaffari S, Shoaran M
Cardiovascular Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Pak J Biol Sci. 2009 May 1;12(9):702-6. doi: 10.3923/pjbs.2009.702.706.
The aim of this study is to evaluate the growth failure in children with Congenital Heart Diseases (CHD) associated with the Pulmonary Hypertension (PH) and cyanosis. Growth parameters including weight, height and head circumference of 120 cases with congenital heart defects aged 6 months to 14 years were compared with standard growth curves (50th percentile) between November 2007 and November, 2008. Of all, sixty five (54.1%) were male and 55 (45.8%) were female. The patients were classified into four groups based on the presence or absence of PH and cyanosis. The gap between chronological age and bone age (BA) for all subjects was determined. Growth disturbance in weight, height and head circumference was detected in 80 (66.7%), 79 (65.8%) and 41 (34.2%) of the patients, respectively. Bone age delay was seen in fifty five percent of the cases. Generally, delay in all parameters was more seen in acyanotic patients with pulmonary hypertension. In subjects with cyanosis whether in addition to PH or not, bone age was significantly retarded. Etiology of growth failure in children with CHD is multifactorial. Further studies are required to assess the role of different factors in this field.
本研究的目的是评估患有先天性心脏病（CHD）并伴有肺动脉高压（PH）和发绀的儿童的生长发育迟缓情况。在2007年11月至2008年11月期间，将120例年龄在6个月至14岁的先天性心脏缺陷患儿的生长参数，包括体重、身高和头围，与标准生长曲线（第50百分位数）进行比较。其中，65例（54.1%）为男性，55例（45.8%）为女性。根据是否存在PH和发绀将患者分为四组。测定了所有受试者的实际年龄与骨龄（BA）之间的差距。分别在80例（66.7%）、79例（65.8%）和41例（34.2%）患者中检测到体重、身高和头围的生长障碍。55%的病例出现骨龄延迟。一般来说，在无发绀的肺动脉高压患者中，所有参数的延迟更为常见。在有发绀的受试者中，无论是否合并PH，骨龄均显著延迟。CHD患儿生长发育迟缓的病因是多因素的。需要进一步研究以评估该领域不同因素的作用。
