神经垂体肽选择性抑制蜗牛神经元中的高电压激活钙电流。

Neurohypophysial peptides selectively depressed high voltage-activated Ca-current in snail neurons.

作者信息

Osipenko O N, Kiss T

机构信息

Department of General Physiology of the Nervous System, A.A. Bogomoletz Institute, Academy of Sciences of the Ukrainian S.S.R., Kiev.

出版信息

Neurosci Lett. 1990 Nov 27;120(1):9-12. doi: 10.1016/0304-3940(90)90155-3.

DOI:10.1016/0304-3940(90)90155-3

PMID:1963481

Abstract

It was found that neurohypophysial peptides oxytocin and Lys-vasopressin selectively decreased the high voltage-activated component of the inward Ca-current in voltage-clamped Helix pomatia identified neurons in a dose- and time-dependent manner. This effect was unaffected or further enhanced applying phosphodiesterases inhibitors. It is suggested that suppression of high voltage-activated current was due to the activation of the adenylate cyclase system, likely protein kinase A.

摘要

研究发现，神经垂体肽催产素和赖氨酸加压素以剂量和时间依赖性方式选择性降低了电压钳制的苹果螺（Helix pomatia）鉴定神经元中内向钙电流的高电压激活成分。应用磷酸二酯酶抑制剂后，这种效应未受影响或进一步增强。提示高电压激活电流的抑制是由于腺苷酸环化酶系统（可能是蛋白激酶A）的激活所致。