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The effects of aluminium (Al) on calcium (Ca) currents were investigated by using the conventional two-electrode voltage clamp technique in Helix pomatia neurons. The peak amplitude, kinetics, and voltage dependence of activation and inactivation of the Ca currents were studied in the presence of 10(-5)-10(-3) M AlCl3, at pH 6. 2. Al prolonged the rising phase of the Ca currents and therefore increased the time to peak at each command voltage step used. 3. There was no significant influence of Al on the peak amplitude of the Ca currents, but the voltage dependence of the time to peak, activation, and inactivation of the Ca currents shifted to more positive potentials as a consequence of Al treatment. 4. The leak currents were not influenced by Al up to 1 mM, which was the maximal dose applied. 5. The results support the suggestion that Al may modify the Ca homeostasis and that it exerts a neurotoxic effect, at least in part, by modulation of the Ca current of the neuronal membrane.

采用传统的双电极电压钳技术，在苹果螺神经元中研究了铝（Al）对钙（Ca）电流的影响。在pH值为6时，于10⁻⁵ - 10⁻³ M三氯化铝存在的情况下，研究了钙电流的峰值幅度、动力学以及激活和失活的电压依赖性。
铝延长了钙电流的上升相，因此在每个使用的指令电压阶跃下增加了达到峰值的时间。
铝对钙电流的峰值幅度没有显著影响，但由于铝处理，钙电流达到峰值的时间、激活和失活的电压依赖性向更正的电位偏移。
高达1 mM（所应用的最大剂量）的铝对漏电流没有影响。
这些结果支持以下观点：铝可能会改变钙稳态，并且它至少部分地通过调节神经元膜的钙电流发挥神经毒性作用。

The effects of aluminium (Al) on calcium (Ca) currents were investigated by using the conventional two-electrode voltage clamp technique in Helix pomatia neurons. The peak amplitude, kinetics, and voltage dependence of activation and inactivation of the Ca currents were studied in the presence of 10(-5)-10(-3) M AlCl3, at pH 6. 2. Al prolonged the rising phase of the Ca currents and therefore increased the time to peak at each command voltage step used. 3. There was no significant influence of Al on the peak amplitude of the Ca currents, but the voltage dependence of the time to peak, activation, and inactivation of the Ca currents shifted to more positive potentials as a consequence of Al treatment. 4. The leak currents were not influenced by Al up to 1 mM, which was the maximal dose applied. 5. The results support the suggestion that Al may modify the Ca homeostasis and that it exerts a neurotoxic effect, at least in part, by modulation of the Ca current of the neuronal membrane.

采用传统的双电极电压钳技术，在苹果螺神经元中研究了铝（Al）对钙（Ca）电流的影响。在pH值为6时，于10⁻⁵ - 10⁻³ M三氯化铝存在的情况下，研究了钙电流的峰值幅度、动力学以及激活和失活的电压依赖性。
铝延长了钙电流的上升相，因此在每个使用的指令电压阶跃下增加了达到峰值的时间。
铝对钙电流的峰值幅度没有显著影响，但由于铝处理，钙电流达到峰值的时间、激活和失活的电压依赖性向更正的电位偏移。
高达1 mM（所应用的最大剂量）的铝对漏电流没有影响。
这些结果支持以下观点：铝可能会改变钙稳态，并且它至少部分地通过调节神经元膜的钙电流发挥神经毒性作用。

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