Fortin Michael, Kaplan Justin, Pham Khoa, Kirk Sharon, Andrade Rodrigo B
Department of Chemistry, Temple University, Philadelphia, Pennsylvania 19122, USA.
Org Lett. 2009 Aug 20;11(16):3594-7. doi: 10.1021/ol901313z.
Two classes of gem-dimethyl 4-n-pentenyl glycosides (i.e., C2-series and C3-series) have been prepared and studied in both the glycosylation and hydrolysis manifolds utilizing NBS as the sole stoichiometric activator. These novel glycosylating agents, which are analogues of Fraser-Reid's 4-n-pentenyl glycosyl donors, show increased reactivity in side-by-side studies by virtue of the gem-dimethyl effect.
已经制备了两类偕二甲基4-正戊烯基糖苷（即C2系列和C3系列），并在糖基化和水解过程中使用NBS作为唯一的化学计量活化剂进行了研究。这些新型糖基化试剂是弗雷泽-里德4-正戊烯基糖基供体的类似物，在并行研究中由于偕二甲基效应而显示出更高的反应活性。
