Cai Denise J, Shuman Tristan, Gorman Michael R, Sage Jennifer R, Anagnostaras Stephan G
Department of Psychology, UCSD, 9500 Gilman Drive 0109, La Jolla, CA 92093-0109, USA.
Behav Neurosci. 2009 Aug;123(4):713-9. doi: 10.1037/a0016415.
Sleep has been implicated as playing a critical role in memory consolidation. Emerging evidence suggests that reactivation of memories during sleep may facilitate the transfer of declarative memories from the hippocampus to the neocortex. Previous rodent studies have utilized sleep-deprivation to examine the role of sleep in memory consolidation. The present study uses a novel, naturalistic paradigm to study the effect of a sleep phase on rodent Pavlovian fear conditioning, a task with both hippocampus-dependent and -independent components (contextual vs. cued memories). Mice were trained 1 hour before their sleep/rest phase or awake/active phase and then tested for contextual and cued fear 12 or 24 hr later. The authors found that hippocampus-dependent contextual memory was enhanced if tested after a sleep phase within 24 hr of training. This enhancement was specific to context, not cued, memory. These findings provide direct evidence of a role for sleep in enhancing hippocampus-dependent memory consolidation in rodents and detail a novel paradigm for examining sleep-induced memory effects.
睡眠被认为在记忆巩固中起着关键作用。新出现的证据表明，睡眠期间记忆的重新激活可能有助于将陈述性记忆从海马体转移到新皮层。先前的啮齿动物研究利用睡眠剥夺来研究睡眠在记忆巩固中的作用。本研究采用一种新颖的、自然主义的范式来研究睡眠阶段对啮齿动物巴甫洛夫恐惧条件反射的影响，这是一项具有海马体依赖和非依赖成分（情境记忆与线索记忆）的任务。小鼠在睡眠/休息阶段或清醒/活动阶段前1小时接受训练，然后在12或24小时后测试情境恐惧和线索恐惧。作者发现，如果在训练后24小时内的睡眠阶段后进行测试，海马体依赖的情境记忆会增强。这种增强特定于情境记忆，而非线索记忆。这些发现为睡眠在增强啮齿动物海马体依赖的记忆巩固中的作用提供了直接证据，并详细介绍了一种用于研究睡眠诱导记忆效应的新范式。
