偶氮染料标记肽的便捷高效制备方法。
Convenient and efficient preparations of azodye-labeled peptides.
作者信息
Katritzky Alan R, Chen Qi-Yin, Tala Srinivasa R
机构信息
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA.
出版信息
Chem Biol Drug Des. 2009 Jun;73(6):611-7. doi: 10.1111/j.1747-0285.2009.00813.x.
Abstract
N-(4-Arylazobenzoyl)-1H-benzotriazoles 15a, 15b react with dipeptides 12a-d, (12d+12d') and tripeptides 14a, 14b to give azodye labeled-dipeptides (16a-e), (16d+16d'), (16e+16e') and -tripeptides 16f, 16g in high yields (73-93%) with retention of chirality.
摘要
N-(4-芳基偶氮苯甲酰基)-1H-苯并三唑15a、15b与二肽12a-d、(12d + 12d')和三肽14a、14b反应，以高收率(73 - 93%)得到偶氮染料标记的二肽(16a - e)、(16d + 16d')、(16e + 16e')和三肽16f、16g，且手性保持不变。
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