Xia Liang-Ping, Zhou Fei-Fei, Yang Ming-Tian, Liu Qiang
State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, P.R. China.
Ai Zheng. 2009 Jun;28(6):668-72.
Aurora kinases play key roles in the transition of G2/M phase by regulating functions of centrosomes and microtubules. Overexpression of Aurora-A, a new oncogene, can induce centrosome amplification, aneuploidy and tumor formation. Aurora kinases are closely associated with breast cancer. In this article, we reviewed the mechanisms of Aurora kinases inducing tumorigenesis of breast cancer via interacting with p53 gene, BRCA1 gene, PTEN/PI3K/AKT pathway, gene polymorphism, estrogen, and so on, analyzed the expression of Aurora kinases in breast cancer and its relationship with prognosis.
极光激酶通过调节中心体和微管的功能在G2/M期转换中发挥关键作用。新型癌基因Aurora-A的过表达可诱导中心体扩增、非整倍体形成及肿瘤发生。极光激酶与乳腺癌密切相关。在本文中，我们综述了极光激酶通过与p53基因、BRCA1基因、PTEN/PI3K/AKT通路、基因多态性、雌激素等相互作用诱导乳腺癌肿瘤发生的机制，分析了极光激酶在乳腺癌中的表达及其与预后的关系。
