Suman Shikha, Mishra Ashutosh
Division of Applied Sciences, Indian Institute of Information Technology, Allahabad, Uttar Pradesh 211012, India.
Oncol Lett. 2018 Jan;15(1):1125-1132. doi: 10.3892/ol.2017.7368. Epub 2017 Nov 8.
Gene markers are crucial for cancer prognosis and treatment. Previous studies have placed greater emphasis on individual diagnostic genes, thereby ignoring systemic-level attributes across diseases. Female-specific cells namely, breast, endometrium, cervical, ovarian and vulvar cells are highly susceptible to cancer. To date, a limited number of molecular studies have been performed that evaluate common biological processes across gynecological types of cancer. Differentially expressed genes in breast, cervical, endometrial, vulvar and ovarian cancer were utilized to construct protein-protein interaction networks, and to identify a common module across the five cancer types. A single common module with 8 nodes and 26 edges was mined among the five cancer systems. In total, four hub genes were present across the five cancer gene sets. Genes in the common module were enriched for the common pathways and associated diseases. The aurora kinase pathway was revealed to be conserved across the five cancer types surveyed. The present study, therefore, revealed that the aurora kinase pathway has a crucial function in the pathogenesis of the five aforementioned gynecological types of cancer through cross-tumor conservation.
基因标志物对癌症的预后和治疗至关重要。以往的研究更侧重于单个诊断基因，从而忽略了疾病的系统层面属性。女性特异性细胞，即乳腺、子宫内膜、宫颈、卵巢和外阴细胞，极易患癌。迄今为止，针对妇科癌症类型间共同生物学过程进行评估的分子研究数量有限。利用乳腺癌、宫颈癌、子宫内膜癌、外阴癌和卵巢癌中差异表达的基因构建蛋白质-蛋白质相互作用网络，并识别出这五种癌症类型中的一个共同模块。在这五个癌症系统中挖掘出了一个由8个节点和26条边组成的单一共同模块。在这五个癌症基因集中总共存在4个枢纽基因。共同模块中的基因在共同通路和相关疾病方面得到了富集。结果显示极光激酶通路在所调查的五种癌症类型中是保守的。因此，本研究表明极光激酶通路通过跨肿瘤保守性在上述五种妇科癌症类型的发病机制中具有关键作用。
