Kurtin Sandra E
Arizona Cancer Center, 3838 N.Campbell Ave, Tucson, AZ 85719, USA.
Semin Oncol Nurs. 2009 Aug;25(3):183-92. doi: 10.1016/j.soncn.2009.05.001.
To discuss current clinical recommendations for treatment of squamous cell carcinoma of the head and neck (SCCHN), to identify common toxicities associated with combined chemoradiotherapy or chemotherapy alone, and describe strategies for management of the most common treatment-related toxicities.
Current research, published literature, National Comprehensive Cancer Network Clinical Practice Guidelines, American Society of Clinical Oncology, and Oncology Nursing Society.
Advances in options for systemic therapy for SCCHN have provided hope for patients with this disease. However, effective management of these patients requires a proactive and persistent multidisciplinary treatment approach, including toxicity management.
Careful evaluation of each patient before initiating treatment with the goals of therapy reviewed by the multidisciplinary team, the patient, and the caregivers, will allow selection of the most appropriate treatment plan. The goals of therapy should provide guidance in balancing tumor response, toxicity (both acute and late effects), survival, and quality of life.
探讨头颈部鳞状细胞癌（SCCHN）治疗的当前临床建议，确定与单纯放化疗或化疗相关的常见毒性，并描述最常见治疗相关毒性的管理策略。
当前研究、已发表文献、美国国立综合癌症网络临床实践指南、美国临床肿瘤学会及肿瘤护理学会。
SCCHN全身治疗选择的进展为该病患者带来了希望。然而，对这些患者进行有效管理需要积极且持续的多学科治疗方法，包括毒性管理。
在多学科团队、患者及护理人员审查治疗目标后，于开始治疗前对每位患者进行仔细评估，将有助于选择最合适的治疗方案。治疗目标应在平衡肿瘤反应、毒性（急性和晚期效应）、生存率及生活质量方面提供指导。
