氧化白藜芦醇对野生型和耐药性水痘带状疱疹病毒体外复制的抑制活性。
Inhibitory activity of oxyresveratrol on wild-type and drug-resistant varicella-zoster virus replication in vitro.
作者信息
Sasivimolphan Pattaraporn, Lipipun Vimolmas, Likhitwitayawuid Kittisak, Takemoto Masaya, Pramyothin Pornpen, Hattori Masao, Shiraki Kimiyasu
机构信息
Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Phayathai Road, Patumwan, Bangkok 10330, Thailand.
出版信息
Antiviral Res. 2009 Oct;84(1):95-7. doi: 10.1016/j.antiviral.2009.07.010. Epub 2009 Jul 25.
The anti-herpes simplex virus (HSV) compound, oxyresveratrol, purified from a Thai traditional medicinal plant of Artocarpus lakoocha, was evaluated for its anti-varicella-zoster virus (VZV) activity. This compound exhibited IC(50) values (50%-inhibitory concentrations for virus plaque formation) of 12.82, 12.80, 12.99 and 12.82 microg/ml against wild type, thymidine kinase-deficient and two types of DNA polymerase mutants with acyclovir-resistance, respectively. Thus oxyresveratrol showed a broad spectrum of anti-VZV activity with a mechanism of action different from that of acyclovir.
从泰国传统药用植物大叶桂木中提纯得到的抗单纯疱疹病毒（HSV）化合物氧化白藜芦醇，对其抗水痘带状疱疹病毒（VZV）活性进行了评估。该化合物对野生型、胸苷激酶缺陷型以及两种对阿昔洛韦耐药的DNA聚合酶突变型VZV的半数抑制浓度（IC50，即抑制病毒空斑形成的50%浓度）分别为12.82、12.80、12.99和12.82微克/毫升。因此，氧化白藜芦醇显示出广谱抗VZV活性，其作用机制与阿昔洛韦不同。
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