3-脱氧-D-甘露-2-辛酮糖酸（Kdo）的C-（β-D-糖基）类似物的合成作为CMP-Kdo合成酶的潜在抑制剂
Synthesis of C-(beta-D-glycosyl) analogues of 3-deoxy-D-manno-2-octulosonic acid (Kdo) as potential inhibitors of CMP-Kdo synthetase.
作者信息
Wåglund T, Luthman K, Orbe M, Claesson A
机构信息
Department of Organic Pharmaceutical Chemistry, University of Uppsala, Sweden.
出版信息
Carbohydr Res. 1990 Oct 10;206(2):269-76. doi: 10.1016/0008-6215(90)80066-c.
PMID:1963573
Abstract
Eight C-(beta-D-glycosyl) analogues (14-21) of Kdo (3-deoxy-D-manno-2-octulosonic acid) were obtained from isopropylidene-protected ester precursors and tested in vitro for their inhibitory activity on CMP-Kdo synthetase. None had more than minor inhibitory activity.
摘要
从异亚丙基保护的酯前体中获得了8种Kdo（3-脱氧-D-甘露-2-辛酮糖酸）的C-（β-D-糖基）类似物（14-21），并在体外测试了它们对CMP-Kdo合成酶的抑制活性。没有一种具有超过轻微的抑制活性。
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