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Synthesis of a simplified transition-state analogue in an attempt to obtain an inhibitor of CMP-KDO synthetase.

作者信息

Wåglund T, Claesson A

机构信息

Department of Organic Pharmaceutical Chemistry, Uppsala Biomedical Center, University of Uppsala, Sweden.

出版信息

Acta Chem Scand (Cph). 1990 Nov;44(10):1058-61. doi: 10.3891/acta.chem.scand.44-1058.

DOI:10.3891/acta.chem.scand.44-1058
PMID:1964386
Abstract

The thioglycoside 5 of 3-deoxy-beta-D-manno-2-octulosonic acid (beta-KDO) has been synthesized in an attempt to make a simplified transition-state analogue inhibitor of the enzyme CMP-KDO synthetase (3-deoxy-D-manno-octulosonate cytidylyltransferase). Compound 5 was tested in vitro and was found to have no inhibitory activity.

摘要

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