Synthesis of a simplified transition-state analogue in an attempt to obtain an inhibitor of CMP-KDO synthetase.
作者信息
Wåglund T, Claesson A
机构信息
Department of Organic Pharmaceutical Chemistry, Uppsala Biomedical Center, University of Uppsala, Sweden.
出版信息
Acta Chem Scand (Cph). 1990 Nov;44(10):1058-61. doi: 10.3891/acta.chem.scand.44-1058.
Abstract
The thioglycoside 5 of 3-deoxy-beta-D-manno-2-octulosonic acid (beta-KDO) has been synthesized in an attempt to make a simplified transition-state analogue inhibitor of the enzyme CMP-KDO synthetase (3-deoxy-D-manno-octulosonate cytidylyltransferase). Compound 5 was tested in vitro and was found to have no inhibitory activity.
摘要
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