Yakabe A, Ito T, Hayashi K, Yamashita S, Ito T, Sugino N
Division of Obstetrics and Gynecology, National Yamaguchi Hospital.
Nihon Gan Chiryo Gakkai Shi. 1990 Dec 20;25(12):2843-7.
OK-432 and etoposide were administered intravenously to a patient with liver metastasis of ovarian cancer. OK-432 induced IFN-gamma and TNF. SuPS and PPD skin reaction became positive after the therapy. The size of metastatic lesions was reduced significantly (partial response). It is suggested that the combination therapy of OK-432 and etoposide may be effective to the liver metastasis of ovarian cancer.
对一名患有卵巢癌肝转移的患者静脉注射OK-432和依托泊苷。OK-432诱导产生γ干扰素和肿瘤坏死因子。治疗后，结核菌素纯蛋白衍生物（PPD）皮肤试验和旧结核菌素（SuPS）皮肤反应呈阳性。转移灶大小显著缩小（部分缓解）。提示OK-432与依托泊苷联合治疗可能对卵巢癌肝转移有效。
