2009年甲型H1N1猪源流感病毒与以往分离出的流感病毒相似。
2009 Swine-origin influenza A (H1N1) resembles previous influenza isolates.
作者信息
Kingsford Carl, Nagarajan Niranjan, Salzberg Steven L
机构信息
Center for Bioinformatics and Computational Biology, Institute for Advance Computer Studies, University of Maryland, College Park, Maryland, United States of America.
出版信息
PLoS One. 2009 Jul 28;4(7):e6402. doi: 10.1371/journal.pone.0006402.
BACKGROUND
In April 2009, novel swine-origin influenza viruses (S-OIV) were identified in patients from Mexico and the United States. The viruses were genetically characterized as a novel influenza A (H1N1) strain originating in swine, and within a very short time the S-OIV strain spread across the globe via human-to-human contact.
METHODOLOGY
We conducted a comprehensive computational search of all available sequences of the surface proteins of H1N1 swine influenza isolates and found that a similar strain to S-OIV appeared in Thailand in 2000. The earlier isolates caused infections in pigs but only one sequenced human case, A/Thailand/271/2005 (H1N1).
SIGNIFICANCE
Differences between the Thai cases and S-OIV may help shed light on the ability of the current outbreak strain to spread rapidly among humans.
背景
2009年4月，在来自墨西哥和美国的患者中发现了新型猪源流感病毒（S-OIV）。这些病毒经基因鉴定为源自猪的新型甲型流感（H1N1）毒株，并且在很短时间内，S-OIV毒株通过人际接触在全球传播。
方法
我们对H1N1猪流感分离株表面蛋白的所有可用序列进行了全面的计算机搜索，发现2000年在泰国出现了一种与S-OIV相似的毒株。早期分离株在猪中引发感染，但只有一例测序的人类病例，即A/泰国/271/2005（H1N1）。
意义
泰国病例与S-OIV之间的差异可能有助于阐明当前疫情毒株在人群中快速传播的能力。
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