Suzuki Jun-ichi, Isobe Mitsuaki, Morishita Ryuichi, Nagai Ryozo
Department of Advanced Clinical Science and Therapeutics, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8655, Japan.
Mediators Inflamm. 2009;2009:494928. doi: 10.1155/2009/494928. Epub 2009 Jul 19.
Tea polyphenols known as catechins are key components with many biological functions, including anti-inflammatory, antioxidative, and anticarcinogenic effects. These effects are induced by the suppression of several inflammatory factors including nuclear factor-kappa B (NF-kappaB). While these characteristics of catechins have been well documented, actions of catechins as mediators on inflammation-related cardiovascular diseases have not yet been well investigated. In this article, we reviewed recent papers to reveal the anti-inflammatory effects of catechins in cardiovascular diseases. In our laboratory, we performed oral administration of catechins into murine and rat models of cardiac transplantation, myocarditis, myocardial ischemia, and atherosclerosis to reveal the effects of catechins on the inflammation-induced ventricular and arterial remodeling. From our results, catechins are potent agents for the treatment and prevention of inflammation-related cardiovascular diseases because they are critically involved in the suppression of proinflammatory signaling pathways.
被称为儿茶素的茶多酚是具有多种生物学功能的关键成分，包括抗炎、抗氧化和抗癌作用。这些作用是通过抑制包括核因子-κB（NF-κB）在内的多种炎症因子而诱导产生的。虽然儿茶素的这些特性已有充分记录，但儿茶素作为炎症相关心血管疾病介质的作用尚未得到充分研究。在本文中，我们回顾了近期的论文，以揭示儿茶素在心血管疾病中的抗炎作用。在我们的实验室中，我们对心脏移植、心肌炎、心肌缺血和动脉粥样硬化的小鼠和大鼠模型口服儿茶素，以揭示儿茶素对炎症诱导的心室和动脉重塑的影响。根据我们的结果，儿茶素是治疗和预防炎症相关心血管疾病的有效药物，因为它们在抑制促炎信号通路中起着关键作用。
