Jaganathan Saravana Kumar, Mandal Mahitosh
Indian Institute of Technology, West-Bengal, Kharagpur, India.
J Biomed Biotechnol. 2009;2009:830616. doi: 10.1155/2009/830616. Epub 2009 Jul 19.
Honey has been used since long time both in medical and domestic needs, but only recently the antioxidant property of it came to limelight. The fact that antioxidants have several preventative effects against different diseases, such as cancer, coronary diseases, inflammatory disorders, neurological degeneration, and aging, led to search for food rich in antioxidants. Chemoprevention uses various dietary agents rich in phytochemicals which serve as antioxidants. With increasing demand for antioxidant supply in the food, honey had gained vitality since it is rich in phenolic compounds and other antioxidants like ascorbic acid, amino acids, and proteins. Some simple and polyphenols found in honey, namely, caffeic acid (CA), caffeic acid phenyl esters (CAPE), Chrysin (CR), Galangin (GA), Quercetin (QU), Kaempferol (KP), Acacetin (AC), Pinocembrin (PC), Pinobanksin (PB), and Apigenin (AP), have evolved as promising pharmacological agents in treatment of cancer. In this review, we reviewed the antiproliferative and molecular mechanisms of honey and above-mentioned polyphenols in various cancer cell lines.
长期以来，蜂蜜一直被用于医疗和家庭需求，但直到最近它的抗氧化特性才受到关注。抗氧化剂对不同疾病具有多种预防作用，如癌症、冠心病、炎症性疾病、神经退行性变和衰老，这一事实促使人们寻找富含抗氧化剂的食物。化学预防使用各种富含植物化学物质的膳食剂，这些物质可作为抗氧化剂。随着食品中抗氧化剂供应需求的增加，蜂蜜因其富含酚类化合物以及其他抗氧化剂如抗坏血酸、氨基酸和蛋白质而变得备受关注。蜂蜜中发现的一些简单多酚和多酚，即咖啡酸（CA）、咖啡酸苯酯（CAPE）、白杨素（CR）、高良姜素（GA）、槲皮素（QU）、山奈酚（KP）、金合欢素（AC）、松属素（PC）、松属二氢黄酮醇（PB）和芹菜素（AP），已成为治疗癌症的有前景的药物。在本综述中，我们回顾了蜂蜜和上述多酚在各种癌细胞系中的抗增殖和分子机制。
