Berghaus Carsten, Schwarten Melanie, Heumann Rolf, Stoll Raphael
Biomolecular NMR, Faculty of Chemistry and Biochemistry, Ruhr-University of Bochum, Bochum 44780, Germany.
Biomol NMR Assign. 2007 Jul;1(1):45-7. doi: 10.1007/s12104-007-9013-4. Epub 2007 May 22.
Rheb (Ras homologue enriched in brain) is a small GTPase that plays an important role in tuberous sclerosis. Here we present the backbone assignments of rRheb in its GDP-bound state. These assignments now provide a basis for the analysis of the interaction of rRheb with putative factors in order to elucidate the function of this GTPase and its role in the MAP kinase pathway of neuronal cells and in tuberous sclerosis.
Rheb（脑中富集的Ras同源物）是一种小GTP酶，在结节性硬化症中起重要作用。在此，我们展示了处于GDP结合状态的rRheb的主链归属。这些归属现在为分析rRheb与推定因子的相互作用提供了基础，以便阐明这种GTP酶的功能及其在神经元细胞的MAP激酶途径和结节性硬化症中的作用。
