Schwarten Melanie, Berghaus Carsten, Heumann Rolf, Stoll Raphael
Biomolecular NMR, Ruhr-University of Bochum, Bochum 44780, Germany.
Biomol NMR Assign. 2007 Jul;1(1):105-8. doi: 10.1007/s12104-007-9030-3. Epub 2007 Jul 11.
Ras homologue enriched in brain (Rheb) is a small GTPase that plays an important role in tuberous sclerosis. Here we present the backbone assignments of activated rRheb in complex with the non-hydrolisable GTP analogue GppNHp. These assignments now provide a basis for the analysis of rRheb's interaction with putative effectors in order to further elucidate the physiological function of this GTPase and its role in the regulation of neuronal cell volume as well as in tuberous sclerosis.
富含脑的Ras同源物（Rheb）是一种小GTP酶，在结节性硬化症中起重要作用。在这里，我们展示了与非水解性GTP类似物GppNHp结合的活化rRheb的主链归属。这些归属现在为分析rRheb与假定效应器的相互作用提供了基础，以便进一步阐明这种GTP酶的生理功能及其在调节神经元细胞体积以及结节性硬化症中的作用。
