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人增殖细胞核抗原的主链归属

Backbone assignment of human proliferating cell nuclear antigen.

作者信息

Sánchez Ricardo, Torres Daniel, Prieto Jesús, Blanco Francisco J, Campos-Olivas Ramón

机构信息

Spanish National Cancer Center, Madrid, Spain.

出版信息

Biomol NMR Assign. 2007 Dec;1(2):245-7. doi: 10.1007/s12104-007-9068-2. Epub 2007 Nov 30.

DOI:10.1007/s12104-007-9068-2
PMID:19636876
Abstract

PCNA is an essential factor for DNA replication, repair, chromatin metabolism, and effector of cell-cycle regulatory signals. The assignment of backbone (1)H(N), (13)C(alpha), (13)CO, and (15)N, and sidechain (13)C(beta) resonances of the human PCNA homotrimeric ring ( approximately 90 kDa, 261 residues) is reported here.

摘要

增殖细胞核抗原(PCNA)是DNA复制、修复、染色质代谢的重要因子,也是细胞周期调节信号的效应器。本文报道了人PCNA同三聚体环(约90 kDa,261个残基)的主链(1)H(N)、(13)C(α)、(13)CO和(15)N以及侧链(13)C(β)共振的归属。

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