人增殖细胞核抗原的主链归属
Backbone assignment of human proliferating cell nuclear antigen.
作者信息
Sánchez Ricardo, Torres Daniel, Prieto Jesús, Blanco Francisco J, Campos-Olivas Ramón
机构信息
Spanish National Cancer Center, Madrid, Spain.
出版信息
Biomol NMR Assign. 2007 Dec;1(2):245-7. doi: 10.1007/s12104-007-9068-2. Epub 2007 Nov 30.
PMID:19636876
Abstract
PCNA is an essential factor for DNA replication, repair, chromatin metabolism, and effector of cell-cycle regulatory signals. The assignment of backbone (1)H(N), (13)C(alpha), (13)CO, and (15)N, and sidechain (13)C(beta) resonances of the human PCNA homotrimeric ring ( approximately 90 kDa, 261 residues) is reported here.
摘要
增殖细胞核抗原（PCNA）是DNA复制、修复、染色质代谢的重要因子，也是细胞周期调节信号的效应器。本文报道了人PCNA同三聚体环（约90 kDa，261个残基）的主链（1）H（N）、（13）C（α）、（13）CO和（15）N以及侧链（13）C（β）共振的归属。
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