DeMet E M, Chicz-DeMet A, Bell K M, Reist C, Gerner R H
Department of Psychiatry and Human Behavior, University of California, Irvine 92717.
Psychiatry Res. 1990 Dec;34(3):303-13. doi: 10.1016/0165-1781(90)90008-s.
A decreased density of platelet 3H-imipramine (3H-IMI) binding sites has been proposed as a putative trait marker of major depressive illness. However, subsequent studies have demonstrated that the number of such sites is increased so as to be more like normal controls upon chronic treatment with antidepressant drugs. In addition, there is some evidence to suggest that altered 3H-IMI binding may be secondary to elevated plasma cortisol levels which are common in depressed patients and which normalize with remission. The present study compares platelet 3H-imipramine binding, plasma cortisol levels, and clinical improvement of 10 endogenous depressed patients before and after 6 weeks of treatment with imipramine-HCl. Total high affinity 3H-IMI binding sites were further differentiated into two subclasses on the basis of their relative sensitivities to cyanoimipramine (CNIMI) inhibition. Treatment was associated with a significant increase (134%) in CNIMI resistant binding but a decrease (45.2%) in CNIMI sensitive binding. While the former was significantly correlated with posttreatment cortisol levels, no significant correlation was found between cortisol and CNIMI specific binding. Neither site appeared to be directly related to mood state. The significance of these findings to the evaluation of platelet binding as a trait dependent marker is discussed.
血小板3H-丙咪嗪（3H-IMI）结合位点密度降低已被提出作为重度抑郁症的一种假定特质标记。然而，后续研究表明，在使用抗抑郁药物进行长期治疗后，此类位点的数量会增加，从而更接近正常对照。此外，有一些证据表明，3H-IMI结合的改变可能继发于血浆皮质醇水平升高，而血浆皮质醇水平在抑郁症患者中很常见，且在病情缓解时会恢复正常。本研究比较了10例内源性抑郁症患者在接受盐酸丙咪嗪治疗6周前后的血小板3H-丙咪嗪结合、血浆皮质醇水平及临床改善情况。根据它们对氰化丙咪嗪（CNIMI）抑制的相对敏感性，将总高亲和力3H-IMI结合位点进一步分为两个亚类。治疗后，对CNIMI耐药的结合显著增加（134%），而对CNIMI敏感的结合减少（45.2%）。虽然前者与治疗后的皮质醇水平显著相关，但未发现皮质醇与CNIMI特异性结合之间存在显著相关性。这两个位点似乎均与情绪状态无直接关系。本文讨论了这些发现对评估血小板结合作为一种特质依赖性标记的意义。
