DeMet E M, Bell K M, Reist C, Gerner R H, Chicz-DeMet A
Department of Psychiatry and Human Behavior, University of California, Irvine 92717.
Psychiatry Res. 1990 Dec;34(3):315-29. doi: 10.1016/0165-1781(90)90009-t.
Seasonal variations in cyanoimipramine (CNIMI) sensitive and CNIMI resistant subclasses of platelet 3H-imipramine (3H-IMI) binding sites were studied in depressed patients and normal volunteers. Sinusoidal rhythms of the binding of both subclasses were found in patients and controls with peak levels in mid-February. Patient values of CNIMI sensitive binding fluctuated about a yearly average that was 32% lower than the average of controls. Patient deviations from the normal pattern were apparently bimodally distributed, whereas those of controls were normally distributed. CNIMI resistant binding was also normally distributed in controls, but not in depressed patients, although patient mesor values were not lower than those of controls. Platelet binding was not correlated with the severity of illness as measured by the Hamilton Rating Scale for Depression, and individual symptoms failed to discriminate between patients with high and low Bmax values.
在抑郁症患者和正常志愿者中研究了血小板3H-丙咪嗪（3H-IMI）结合位点的氰化丙咪嗪（CNIMI）敏感和CNIMI抗性亚类的季节性变化。在患者和对照中发现两个亚类结合的正弦节律，在2月中旬达到峰值水平。CNIMI敏感结合的患者值围绕年平均值波动，该年平均值比对照平均值低32%。患者与正常模式的偏差明显呈双峰分布，而对照的偏差呈正态分布。CNIMI抗性结合在对照中也呈正态分布，但在抑郁症患者中不呈正态分布，尽管患者的中值并不低于对照。血小板结合与用汉密尔顿抑郁评定量表测量的疾病严重程度无关，并且个体症状未能区分高Bmax值和低Bmax值的患者。
