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G蛋白激活的内向整流钾通道1（GIRK1）细胞质区域的主链共振归属

Backbone resonance assignments for the cytoplasmic regions of G protein-activated inwardly rectifying potassium channel 1 (GIRK1).

作者信息

Yokogawa Mariko, Muramatsu Takahiro, Takeuchi Koh, Osawa Masanori, Shimada Ichio

机构信息

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

出版信息

Biomol NMR Assign. 2009 Jun;3(1):125-8. doi: 10.1007/s12104-009-9156-6. Epub 2009 Apr 8.

DOI:10.1007/s12104-009-9156-6
PMID:19636962
Abstract

G protein-activated inwardly rectifying potassium channel (GIRK) plays crucial roles in regulating heart rate and neuronal excitability in eukaryotic cells. A variety of ligands, including heterotrimeric G protein betagamma subunits (G betagamma), bind to the cytoplasmic regions of GIRK and modulate its activity. We established the backbone resonance assignments of (2)H/(13)C/(15)N-labeled cytoplasmic regions of mouse GIRK1, which form a tetramer with a molecular weight of 96 K.

摘要

G蛋白激活的内向整流钾通道（GIRK）在真核细胞中调节心率和神经元兴奋性方面发挥着关键作用。多种配体，包括异源三聚体G蛋白βγ亚基（Gβγ），与GIRK的胞质区域结合并调节其活性。我们确定了小鼠GIRK1的（2）H/（13）C/（15）N标记胞质区域的主链共振归属，该区域形成分子量为96 K的四聚体。

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