业余拳击手中神经元特异性烯醇化酶向血清中的持续释放。
Sustained release of neuron-specific enolase to serum in amateur boxers.
作者信息
Zetterberg Henrik, Tanriverdi Fatih, Unluhizarci Kursad, Selcuklu Ahmet, Kelestimur Fahrettin, Blennow Kaj
机构信息
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden.
出版信息
Brain Inj. 2009 Aug;23(9):723-6. doi: 10.1080/02699050903120399.
PRIMARY OBJECTIVE
We assess the potential of a panel of serum biomarkers to identify chronic neuronal injury in amateur boxers as compared to healthy controls without any history of head trauma.
RESEARCH DESIGN
Observational case-control study.
METHODS AND PROCEDURES
A panel of serum biomarkers was measured by a novel biochip array technique on the Evidence Investigator. Serum samples were taken after a 2-month period of nonparticipation in boxing.
MAIN OUTCOMES AND RESULTS
Boxers had higher serum levels of neuron-specific enolase (NSE, median [range] 11 [2.3-41] ng/mL) than controls (4.8 [0.78-27] ng/mL, p = 0.014) but unchanged levels of the other brain damage biomarker candidates, S-100B, brain-derived neurotrophic factor and heart-type fatty acid binding protein.
CONCLUSIONS
The more than doubled median serum level of NSE in boxers after an extended resting period suggests that repetitive head trauma results in sustained release of this brain-specific protein to the peripheral circulation.
主要目标
我们评估一组血清生物标志物在识别业余拳击手慢性神经元损伤方面的潜力，并与无任何头部创伤史的健康对照者进行比较。
研究设计
观察性病例对照研究。
方法与步骤
通过新型生物芯片阵列技术在Evidence Investigator上测量一组血清生物标志物。在停止拳击活动2个月后采集血清样本。
主要结局与结果
拳击手的神经元特异性烯醇化酶（NSE，中位数[范围]11[2.3 - 41]ng/mL）血清水平高于对照组（4.8[0.78 - 27]ng/mL，p = 0.014），但其他脑损伤生物标志物候选物S - 100B、脑源性神经营养因子和心脏型脂肪酸结合蛋白的水平没有变化。
结论
在延长的休息期后，拳击手中NSE的血清中位数水平增加了一倍多，这表明重复性头部创伤会导致这种脑特异性蛋白持续释放到外周循环中。
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