Department of Biomedical Science, University Putra Malaysia, Serdang, Malaysia.
Planta Med. 2010 Feb;76(2):107-12. doi: 10.1055/s-0029-1185950. Epub 2009 Jul 27.
In the present study, the rhizome essential oil from Zingiber zerumbet (Zingiberaceae) was evaluated for antinociceptive activity using chemical and thermal models of nociception, namely, the acetic acid-induced abdominal writhing test, the hot-plate test and the formalin-induced paw licking test. It was demonstrated that intraperitoneal administration of the essential oil of Z. zerumbet (EOZZ) at the doses of 30, 100 and 300 mg/kg produced significant dose-dependent inhibition of acetic acid-induced abdominal writhing, comparable to that of obtained with acetylsalicylic acid (100 mg/kg). At the same doses, the EOZZ produced significant dose-dependent increases in the latency time in the hot-plate test with respect to controls, and in the formalin-induced paw licking test, the EOZZ also significantly reduced the painful stimulus in both neurogenic and inflammatory phase of the test. In addition, the antinociceptive effect of the EOZZ in the formalin-induced paw licking test as well as hot-plate test was reversed by the nonselective opioid receptor antagonist, naloxone suggesting that the opioid system was involved in its analgesic mechanism of action. On the basis of these data, we concluded that the EOZZ possessed both central and peripheral antinociceptive activities which justifying its popular folkloric use to relieve some pain conditions.
在本研究中，采用化学和热疼痛模型（即醋酸诱导的扭体试验、热板试验和福尔马林诱导的舔足试验）评估了姜黄（姜科）根茎精油的镇痛活性。结果表明，腹腔内给予姜黄精油（EOZZ），剂量为 30、100 和 300mg/kg，可显著抑制醋酸诱导的扭体反应，与乙酰水杨酸（100mg/kg）相当。在相同剂量下，EOZZ 还显著增加了热板试验中相对于对照组的潜伏期，并且在福尔马林诱导的舔足试验中，EOZZ 还显著减轻了试验的神经源性和炎症期的疼痛刺激。此外，非选择性阿片受体拮抗剂纳洛酮逆转了 EOZZ 在福尔马林诱导的舔足试验和热板试验中的镇痛作用，表明阿片系统参与了其镇痛作用机制。基于这些数据，我们得出结论，EOZZ 具有中枢和外周镇痛活性，这也证明了其在民间用于缓解某些疼痛症状的用途。
