[利多卡因和氯丙嗪对环磷酸腺苷刺激的多种线粒体氧化酶活性的预防作用]
[Prevention of cAMP stimulation of activity of various oxidative mitochondrial enzymes with lidocaine and aminazine].
作者信息
Medvedev A E
出版信息
Vopr Med Khim. 1990 Nov-Dec;36(6):74-6.
Lidocaine or aminazine (chlorpromazine) injected to rats or incubated with liver mitochondria prevented NAD-isocitrate dehydrogenase and transhydrogenase activation during the subsequent incubation of mitochondria with cAMP. Integrity of mitochondrial membranes is obligatory for manifestation of the drugs effect. Lidocaine and aminazine-induced desensitization of mitochondria to the cAMP action was apparently realized via alteration in the state (and/or composition) of lipid component of mitochondria. The significance of mitochondria sensitivity to cAMP stimulation is discussed.
向大鼠注射利多卡因或氨丙嗪（氯丙嗪），或将其与肝线粒体一起孵育，可在随后线粒体与环磷酸腺苷（cAMP）孵育期间阻止烟酰胺腺嘌呤二核苷酸异柠檬酸脱氢酶和转氢酶的激活。线粒体膜的完整性对于药物作用的表现是必不可少的。利多卡因和氨丙嗪诱导的线粒体对cAMP作用的脱敏显然是通过线粒体脂质成分状态（和/或组成）的改变实现的。文中讨论了线粒体对cAMP刺激敏感性的意义。
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