Kulinskiĭ V I, Medvedev A I, Kuntsevich A K
Vopr Med Khim. 1986 Sep-Oct;32(5):84-8.
Acute cooling of rats led to stimulation of NAD+-dependent isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH) and NAD(P)+-transhydrogenase (TH) but did not affect the NADP+-ICDH activity in liver, heart and skeletal muscle mitochondria. After pretreatment of the animals with propranolol the stimulating effect was decreased, thus suggesting that endogenous catecholamines and beta-adrenoreceptors are of importance in activation of NAD+-ICDH, SDH and TH. The effects of cooling, noradrenaline and cAMP did not summarize. Role of catecholamines in stimulation of mitochondrial oxidative enzymes under conditions of cooling is discussed.
对大鼠进行急性冷却会刺激肝脏、心脏和骨骼肌线粒体中的NAD+依赖性异柠檬酸脱氢酶（ICDH）、琥珀酸脱氢酶（SDH）和NAD(P)+转氢酶（TH），但不影响NADP+-ICDH的活性。在用普萘洛尔对动物进行预处理后，刺激作用减弱，这表明内源性儿茶酚胺和β-肾上腺素受体在激活NAD+-ICDH、SDH和TH中起重要作用。冷却、去甲肾上腺素和cAMP的作用并不叠加。本文讨论了儿茶酚胺在冷却条件下刺激线粒体氧化酶的作用。
