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Effects of antioxidants on V79 Chinese hamster cells treated with ferric nitrilotriacetate.

作者信息

Takehara Y, Yoshioka T, Namba M

机构信息

Medical Science Laboratory, Kurashiki Center for Adult Diseases, Japan.

出版信息

Acta Med Okayama. 1990 Dec;44(6):287-91. doi: 10.18926/AMO/30430.

DOI:10.18926/AMO/30430
PMID:1963729
Abstract

The cytotoxic effects of ferric nitrilotriacetate (Fe-NTA) have been considered to be caused by free radicals produced by the drug. The present study was carried out to determine whether or not cytotoxic effects of Fe-NTA on cell growth and lipoperoxide formation of Chinese hamster cells were reduced by antioxidants. Using a spin trapping technique, we found that hydroxyl radical formation in the cells increased in the presence of Fe-NTA. Antioxidants, with the exception of superoxide dismutase, slightly inhibited production of the hydroxyl radical. Mannitol significantly reduced lipoperoxide formation, but other antioxidants did not. However, the growth inhibitory effects of Fe-NTA were not attenuated by these antioxidants. These results indicated that the cytotoxic effects of Fe-NTA may be mostly due to unknown factors other than oxygen free radicals.

摘要

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