Nakatsuka S, Tanaka H, Namba M
Department of Urology, Kawasaki Medical School, Okayama, Japan.
Carcinogenesis. 1990 Feb;11(2):257-60. doi: 10.1093/carcin/11.2.257.
Ferric nitrilotriacetate (Fe-NTA) induced dose- and time-dependent mutation of V79 Chinese hamster cells to 6-thioguanine resistance. It also caused dose-related inhibition of metabolic cooperation. However, no significant induction of chromosome aberrations was detected in cells treated with Fe-NTA up to 100 micrograms Fe/ml of the drug even after treatment for 3 days. Our results indicate that Fe-NTA has mutagenic effects on V79 cells and inhibitory effects on cell--cell communication, and these effects may contribute to NTA-Fe-induced neoplastic transformation of mammalian cells.
次氮基三乙酸铁（Fe-NTA）诱导V79中国仓鼠细胞发生剂量和时间依赖性突变，使其对6-硫鸟嘌呤产生抗性。它还引起与剂量相关的代谢协同抑制。然而，即使在处理3天后，用高达100微克铁/毫升该药物处理的细胞中也未检测到明显的染色体畸变诱导。我们的结果表明，Fe-NTA对V79细胞具有诱变作用，对细胞间通讯具有抑制作用，并且这些作用可能有助于NTA-Fe诱导的哺乳动物细胞肿瘤转化。
