Mal'tseva V N, Safronova V G
Tsitologiia. 2009;51(6):467-74.
The review is focused on the participation of polymorphonuclear granulocytes (neutrophils) in development and spreading of a tumor. We consider both the well known functions of neutrophils (degranulation, production of reactive oxygen species (ROS)) and the recently shown one (presentation of an antigene). The special attention is focused on the ambiguity of the neutrophil role in oncogenesis. The dominant view is that neutrophils display exclusively antitumor properties. The update information testifies about protumoral activity of neutrophils: they migrate to a tumor and promote angiogenesis and metastasis at late stages of the tumor. It is interesting that certain components of neutrophil cytotoxic arsenal (ROS, cytokines, specific enzymes) participate both in antitumoral defenses of an organism and protumoral activity.
这篇综述聚焦于多形核粒细胞（中性粒细胞）在肿瘤发生发展及扩散过程中的作用。我们既考虑了中性粒细胞的已知功能（脱颗粒、活性氧（ROS）生成），也考虑了最近发现的功能（抗原呈递）。特别关注的是中性粒细胞在肿瘤发生过程中作用的模糊性。主流观点认为中性粒细胞仅具有抗肿瘤特性。最新信息表明中性粒细胞具有促肿瘤活性：它们会迁移至肿瘤部位，并在肿瘤晚期促进血管生成和转移。有趣的是，中性粒细胞细胞毒性武器库中的某些成分（ROS、细胞因子、特定酶）既参与机体的抗肿瘤防御，也参与促肿瘤活性。
