Dahlberg P E, Busse W W
Section of Allergy, Pulmonary and Critical Care, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.
Clin Exp Allergy. 2009 Sep;39(9):1324-9. doi: 10.1111/j.1365-2222.2009.03322.x. Epub 2009 Jul 23.
Rackemann described the 'intrinsic asthma' population over 50 years ago as a unique subgroup that was characterized by onset of progressive loss of lung function beginning later in life, possibly after a respiratory infection. It has also been associated with a female predominance, aspirin-sensitive bronchospasm, and nasal polyposis. While the aetiology is not understood, we propose that persistent respiratory infections play a central role in the development of intrinsic asthma.
拉克曼在50多年前将“特发性哮喘”人群描述为一个独特的亚组，其特征是肺功能逐渐丧失始于生命后期，可能在呼吸道感染之后。它还与女性占主导、阿司匹林敏感型支气管痉挛和鼻息肉病有关。虽然病因尚不清楚，但我们认为持续性呼吸道感染在特发性哮喘的发展中起核心作用。
