Pavan Barbara, Biondi Carla, Dalpiaz Alessandro
Department of Biology and Evolution, General Physiology Section, University of Ferrara, Ferrara, Italy.
Drug Discov Today. 2009 Oct;14(19-20):982-91. doi: 10.1016/j.drudis.2009.07.007. Epub 2009 Jul 26.
Pharmacological modulation of intracellular cyclic AMP (cAMP) signalling could provide new therapeutic and experimental tools. Although drugs interfering with this pathway have traditionally targeted membrane receptors, the effector enzyme adenylyl cyclase (AC), which functions as a signalling catalyst, also presents an interesting target. Thus, development of isoform-selective stimulator and/or inhibitor compounds for AC could lead to organ-specific pharmacotherapeutics for treating heart failure, cancer and neurodegenerative diseases. In this review, the potential of AC as the object of drug therapy is discussed.
细胞内环磷酸腺苷（cAMP）信号传导的药理学调节可为新的治疗和实验工具提供支持。尽管传统上干扰该信号通路的药物靶向膜受体，但作为信号催化剂发挥作用的效应酶腺苷酸环化酶（AC）也是一个有趣的靶点。因此，开发AC的亚型选择性刺激剂和/或抑制剂化合物可能会产生用于治疗心力衰竭、癌症和神经退行性疾病的器官特异性药物疗法。在这篇综述中，将讨论AC作为药物治疗对象的潜力。
