Barresi V, Grosso M, Giuffrè G, Tuccari G, Barresi G
Department of Human Pathology, University of Messina, Messina, Italy.
J Clin Pathol. 2009 Aug;62(8):705-9. doi: 10.1136/jcp.2009.066175.
Adiponectin (ApN) is a 30 kDa adipocytokine which mediates an antineoplastic effect after binding to its receptors, Adipo-R1 and Adipo-R2. The expression of these receptors has been documented in gastric cancer (GC) cell lines, but only a few data exist on their expression in GC neoplastic tissue.
To investigate the expression of Adipo-R1 and Adipo-R2 in a series of surgically resected GCs and to assess its association with various tumour clinicopathological characteristics as well as with patient survival.
Forty-nine surgically resected GCs were submitted to immunohistochemical assays for Adipo-R1, Adipo-R2 and ApN.
Adipo-R1 and Adipo-R2 immunoexpression was found in 22/49 GCs and in intestinal metaplasia areas near the tumours, whereas only slight immunoreactivity for these proteins was found in adjacent normal gastric epithelium. No ApN expression was encountered in any of the cases analysed. Adipo-R1/Adipo-R2 expression was significantly associated with an intestinal histotype of the tumours and with longer overall survival of the patients.
Intestinal-type GCs often express Adipo-R1/R2 in association with a better prognosis. The presence of these receptors could be exploited for novel anticancer therapies based on ApN addition in GC.
脂联素（ApN）是一种30 kDa的脂肪细胞因子，与它的受体Adipo-R1和Adipo-R2结合后介导抗肿瘤作用。这些受体的表达已在胃癌（GC）细胞系中得到证实，但关于它们在GC肿瘤组织中的表达数据却很少。
研究一系列手术切除的GC中Adipo-R1和Adipo-R2的表达情况，并评估其与各种肿瘤临床病理特征以及患者生存的相关性。
对49例手术切除的GC进行Adipo-R1、Adipo-R2和ApN的免疫组化检测。
在49例GC中的22例以及肿瘤附近的肠化生区域发现了Adipo-R1和Adipo-R2免疫表达，而在相邻正常胃上皮中仅发现这些蛋白的轻微免疫反应性。在所分析的任何病例中均未发现ApN表达。Adipo-R1/Adipo-R2表达与肿瘤的肠型组织学类型以及患者较长的总生存期显著相关。
肠型GC常表达Adipo-R1/R2，预后较好。基于在GC中添加ApN的新型抗癌疗法可利用这些受体的存在。
