Department of Gastroenterology, School of Medicine, Ondokuz Mayis University, Samsun, Turkey.
Department of Gastroenterology, School of Medicine, Uludag University, Bursa, Turkey.
Niger J Clin Pract. 2021 Apr;24(4):608-613. doi: 10.4103/njcp.njcp_302_20.
Adiponectin (ApN) is a 244-amino acid protein mainly secreted from the adipose tissue and involved in various physiological functions. ApN exerts its metabolic effects by binding to two major receptors: adiponectin receptor-1 (Adipo-R1) and adiponectin receptor-2 (Adipo-R2). Recent studies have reported ApN's involvement in the progression of cancer. However, there are no studies evaluating the relationship between Adipo-R1/R2 expression and gastric intestinal metaplasia (IM), which is a predisposing factor in gastric cancer (GC) development, and Helicobacter pylori H. pylori infection.
In this study we aimed to investigate the relationship between the Adipo-R1/-R2 expression and H. pylori infection in patients with GC and gastric IM.
Forty patients that underwent gastric resection and 56 patients that developed gastric IM were included in the study. The Adipo-R1/-R2 expression and the presence of H. pylori were examined immunohistochemically. The univariate analyses showed that the expression of Adipo-R1/-R2 in GC patients was significantly lower compared to both complete metaplasia (CM) and incomplete metaplasia (ICM) patients (p <0.0001 for both).
According to multiple multinomial logistic regression analysis, Adipo-R1/-R2 expression in the CM group was significantly higher than in the GC group (p = 0.05, p = 0.014, respectively). Moreover, Adipo-R1/-R2 expression was significantly higher in ICM group compared to the GC group (p=0.012, p=0.045, respectively). However, in both analyses no significant difference was determined in terms of H. pylori positivity between the groups.
The resulting data suggests that ApN plays a role in GC processes via Adipo-R1/-R2 receptors.
脂联素（ApN）是一种由脂肪组织分泌的 244 个氨基酸的蛋白质，参与多种生理功能。ApN 通过与两种主要受体（脂联素受体 1（Adipo-R1）和脂联素受体 2（Adipo-R2））结合来发挥其代谢作用。最近的研究报道 ApN 参与癌症的进展。然而，目前尚无研究评估 Adipo-R1/R2 表达与胃肠化生（IM）之间的关系，IM 是胃癌（GC）发展的一个潜在因素，以及幽门螺杆菌（H. pylori）感染。
本研究旨在探讨 GC 和胃 IM 患者中 Adipo-R1/-R2 表达与 H. pylori 感染的关系。
纳入 40 例接受胃切除术的患者和 56 例发生胃 IM 的患者进行研究。采用免疫组织化学方法检测 Adipo-R1/-R2 的表达和 H. pylori 的存在。单因素分析显示，GC 患者的 Adipo-R1/-R2 表达明显低于完全化生（CM）和不完全化生（ICM）患者（均为 p <0.0001）。
根据多分类逻辑回归分析，CM 组的 Adipo-R1/-R2 表达明显高于 GC 组（p = 0.05，p = 0.014）。此外，ICM 组的 Adipo-R1/-R2 表达明显高于 GC 组（p=0.012，p=0.045）。然而，在这两种分析中，各组之间 H. pylori 阳性率均无显著差异。
研究结果表明，ApN 通过 Adipo-R1/-R2 受体在 GC 过程中发挥作用。
