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[Biochemical markers of bone turnover. New aspect. Nitric oxide synthase and bone metabolism].

作者信息

Sabanai Ken, Tsutsui Masato, Sakai Akinori, Nakamura Toshitaka, Shimokawa Hiroaki, Yanagihara Nobuyuki

机构信息

Department of Orthopaedic Surgery, Tohoku Rosai Hospital/Department of Orthopaedic Surgery, School of Medicine University of Occupational and Enviromental Health.

出版信息

Clin Calcium. 2009 Aug;19(8):1133-41.

PMID:19638697
Abstract

It remains to be determined the role of the nitric oxide synthase (NOS) system in bone metabolism. We addressed this point in mice with complete disruption of the NOS system (triply n/i/eNOS(-/-) mice) that we have recently developed, and clarified that the triply NOS( - / - ) mice manifested increased bone mineral density and accelerated bone turnover in vivo. These results provide the first direct evidence that the entire NOS system plays an important role in the regulation of bone metabolism.

摘要

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