用于生物传感的表面等离子体共振成像

Surface plasmon resonance imaging for biosensing.

作者信息

Paul S, Vadgama P, Ray A K

机构信息

Queen Mary, University of London, School of Engineering and Materials Science, London, UK.

出版信息

IET Nanobiotechnol. 2009 Sep;3(3):71-80. doi: 10.1049/iet-nbt.2008.0012.

DOI:10.1049/iet-nbt.2008.0012

PMID:19640160

Abstract

Surface plasmon resonance imaging (SPRI) is a useful tool for the study of surface biomolecular interactions allowing for label-free detection and elegant instrumentation. SPRI imaging system is described in this review with an emphasis on recent applications with examples of different biological interactions and high throughput analysis. Signal amplification in SPRI using nanoparticle and waveguide-based optical coupling is introduced. Finally the detection sensitivity of the SPRI system is examined in terms of other competitive methods.

摘要

表面等离子体共振成像（SPRI）是研究表面生物分子相互作用的有用工具，可实现无标记检测且仪器精良。本综述介绍了SPRI成像系统，重点是其近期应用，包括不同生物相互作用的实例和高通量分析。文中还介绍了利用纳米颗粒和基于波导的光耦合在SPRI中进行信号放大的方法。最后，将SPRI系统的检测灵敏度与其他竞争方法进行了比较。