Tan G H, Taib Nur Aishah, Choo W Y, Teo S H, Yip Cheng Har
Dept of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Asian Pac J Cancer Prev. 2009 Jul-Sep;10(3):395-8.
Triple negative (TN) breast cancers are defined by a lack of expression of oestrogen, progesterone, and HER2 receptors. They tend to have a higher grade, with a poorer outcome compared to non-TN breast cancers.
The aim of this study is to determine the incidence of TN breast cancer in an Asian country consisting of Malays, Chinese and Indians, and to determine the factors associated with this type of breast cancer.
The incidence of TN breast cancer in the University Malaya Medical Center is 17.6%. There is no significant difference amongst the Malays, Chinese and Indians. In bivariate analysis, TN breast cancer was significantly associated with younger age and Grade 3. However, in multivariate analysis using logistic regression, TN breast cancer was only associated with Grade 3.
The incidence of TN breast cancer in our study is similar to other studies, and associated with a higher grade.
三阴性（TN）乳腺癌的定义是缺乏雌激素、孕激素和HER2受体的表达。与非TN乳腺癌相比，它们往往分级更高，预后更差。
本研究的目的是确定一个由马来人、华人及印度人组成的亚洲国家中TN乳腺癌的发病率，并确定与这类乳腺癌相关的因素。
马来亚大学医学中心TN乳腺癌的发病率为17.6%。马来人、华人及印度人之间无显著差异。在双变量分析中，TN乳腺癌与较年轻年龄及3级显著相关。然而，在使用逻辑回归的多变量分析中，TN乳腺癌仅与3级相关。
我们研究中TN乳腺癌的发病率与其他研究相似，且与更高分级相关。
