Yeh Janet, Chun Jennifer, Schwartz Shira, Wang Annie, Kern Elizabeth, Guth Amber A, Axelrod Deborah, Shapiro Richard, Schnabel Freya
Department of Surgery, New York University Langone Medical Center, New York, NY, USA.
School of Medicine, New York University Langone Medical Center, New York, NY, USA.
Int J Breast Cancer. 2017;2017:1796145. doi: 10.1155/2017/1796145. Epub 2017 Aug 17.
The purpose of this study was to compare and contrast the clinical characteristics of the triple negative breast cancer (TNBC) and non-TNBC patients, with a particular focus on genetic susceptibility and risk factors prior to diagnosis.
Our institutional database was queried for all patients diagnosed with invasive breast cancer between January 2010 and May 2016.
Out of a total of 1964 patients, 190 (10%) patients had TNBC. The median age for both TNBC and non-TNBC was 59 years. There was a significantly higher proportion of African American and Asian patients with TNBC ( = 0.0003) compared to patients with non-TNBC. BRCA1 and BRCA2 were significantly associated with TNBC ( < 0.0001, = 0.0007). A prior history of breast cancer was significantly associated with TNBC ( = 0.0003). There was no relationship observed between TNBC and a history of chemoprevention or patients who had a history of AH or LCIS.
We found that having Asian ancestry, a prior history of breast cancer, and a BRCA1 or BRCA2 mutation all appear to be positively associated with TNBC. In order to develop more effective treatments, better surveillance, and improved prevention strategies, it is necessary to improve our understanding of the population at risk for TNBC.
本研究旨在比较和对比三阴性乳腺癌（TNBC）和非TNBC患者的临床特征，特别关注诊断前的遗传易感性和风险因素。
查询我们机构数据库中2010年1月至2016年5月期间所有诊断为浸润性乳腺癌的患者。
在总共1964例患者中，190例（10%）为TNBC患者。TNBC和非TNBC患者的中位年龄均为59岁。与非TNBC患者相比，TNBC患者中非洲裔美国人和亚洲人的比例显著更高（P = 0.0003）。BRCA1和BRCA2与TNBC显著相关（P < 0.0001，P = 0.0007）。乳腺癌既往史与TNBC显著相关（P = 0.0003）。未观察到TNBC与化学预防史或有非典型增生（AH）或小叶原位癌（LCIS）病史的患者之间存在关联。
我们发现亚洲血统、乳腺癌既往史以及BRCA1或BRCA2突变似乎均与TNBC呈正相关。为了开发更有效的治疗方法、更好的监测手段和改进预防策略，有必要加深我们对TNBC高危人群的了解。
