Sood Neelam, Nigam Jitendra Singh
Department of Pathology, Deen Dayal Upadhyay Hospital, Hari Nagar, New Delhi 110066, India.
Department of Pathology, Saraswathi Institute of Medical Sciences, Anwarpur, Hapur, Uttar Pradesh 245304, India.
Patholog Res Int. 2014;2014:141864. doi: 10.1155/2014/141864. Epub 2014 Oct 23.
Purpose. Triple-negative breast cancer (TNBC) is defined by the loss of expression of ER, PR, and Her2neu expressions. The aim of this study was to examine the expression of the EGFR, CK5, and Ki-67 among triple-negative breast cancer cases and to correlate the expression of the basal markers with the clinicopathological prognostic parameters. Materials and Methods. Thirty-six female patients with TNBC based on ER, PR, and the HER2neu negativities were studied by immunohistochemistry for EGFR, CK5, and Ki-67 expression. Statistical analysis was done using the SPSS software version 20. Results. The mean and median ages were 45.18 years and 46.70 years, respectively. Infiltrating ductal carcinoma NOS was the predominant histopathological type (29/36 [80.6%]). The commonest histological grade was grade 2 (17/36 [47.2%]). Tumour necrosis was seen in 16/36 (44.4%) patients. Infiltrative margins were shown in 69.44% (25/36) cases. Ki-67 was positive in 80.56% (29/36) cases, 61.11% (22/36) were CK5-positive, and 86.11% (31/36) were EGFR-positive. The only significant positive association observed was between the CK5 and histological grade (P < 0.05). Conclusion. CK5 shows a statistically significantly correlation with TNBC histological grade. The majority of the specimens show EGFR expression. Therefore TNBCs could potentially benefit from EGFR-targeted therapeutic strategies.
目的。三阴性乳腺癌（TNBC）的定义为雌激素受体（ER）、孕激素受体（PR）及人表皮生长因子受体2（Her2neu）表达缺失。本研究旨在检测三阴性乳腺癌病例中表皮生长因子受体（EGFR）、细胞角蛋白5（CK5）及Ki-67的表达情况，并将这些基底标志物的表达与临床病理预后参数进行关联分析。材料与方法。选取36例基于ER、PR及HER2neu均为阴性的三阴性乳腺癌女性患者，采用免疫组织化学方法检测EGFR、CK5及Ki-67的表达。使用SPSS 20.0软件进行统计分析。结果。患者的平均年龄和中位年龄分别为45.18岁和46.70岁。浸润性导管癌NOS是主要的组织病理学类型（29/36 [80.6%]）。最常见的组织学分级为2级（17/36 [47.2%]）。16/36（44.4%）的患者可见肿瘤坏死。69.44%（25/36）的病例显示为浸润性边缘。80.56%（29/36）的病例Ki-67呈阳性，61.11%（22/36）为CK5阳性，86.11%（31/36）为EGFR阳性。观察到的唯一显著正相关是CK5与组织学分级之间（P < 0.05）。结论。CK5与三阴性乳腺癌的组织学分级呈统计学显著相关性。大多数标本显示EGFR表达。因此，三阴性乳腺癌可能从EGFR靶向治疗策略中获益。
